), the most prevalent condition affecting the female reproductive system in women aged 15 to 44, is linked to such serious health risks as preterm birth, gynecological malignancies and sexually transmitted diseases.
But effective long-term treatments for BV are limited: More than half experience a recurrence within six months, according to
With a $1.5 million grant from the researchers at 扒哥黑料 School of Medicine will study the dynamics of BV in hopes of identifying a more effective approach.
鈥淲e hope to gain insights into promoting health within the human microbiome and to find better ways to prevent and treat infections that involve multiple types of bacteria,鈥 said Gina Lewin, assistant professor in the Department of Pathology at the School of Medicine. 鈥淭his research is a promising step toward better treatments for BV and highlights Case Western Reserve鈥檚 commitment to advancing women鈥檚 health.鈥
BV, which causes pain, odor and discharge鈥攊n addition to possible serious health risks鈥攐ccurs from an imbalance in vaginal bacteria.
Lewin and her team of microbial ecologists鈥攁lso part of Case Western Reserve鈥檚 Center for Global Health and Diseases鈥攚ill investigate the diversity of bacteria in the vaginal microbiome at a single-cell level. They will focus on the different strains of bacteria present and their individual behaviors.
Lewin鈥檚 approach will examine the genetic variations within thousands of bacterial cells from vaginal microbiome, which could lead to understanding how BV develops and why some women respond better to treatment than others. This aspect of the study will work with established patient groups in collaboration with researchers at the Canada.
In addition, researchers will examine how individual bacterial cells behave and interact with a host environment, using advanced sequencing technology.
For more information contact Patty Zamora at patty.zamora@case.edu.